3/24/2023 – Congratulations to Colleen for successfully defending her dissertation and becoming Dr. Chernowsky!
3/16/2023 – Congratulations to Minji, Diana, Karina, Uriel, Alison, and Ilia on developing a diastereoselective cyclopropanation method using the electrochemical dication pool strategy!
Cyclopropanes are desirable structural motifs with valuable applications in drug discovery and beyond. Established alkene cyclopropanation methods give rise to cyclopropanes with a limited array of substituents, are difficult to scale, or both. Herein, we …
2/25/2023 – Congratulations to Oliver, Alyah, Myriam, Charles, and Desiree on their work to develop a practical deoxygenation protocol with formate and light (and an acid promoter)!
A new protocol for alcohol deoxygenation that functions across a wide range of alcohol structures is reported. This approach combines the reductive potency of carbon dioxide radical anion with acidic additives to promote the kinetically …
2/16/2023 – Congratulations to Diana for successfully defending their dissertation and becoming Dr. Wang!
2/7/2023 – Congratulations to Oliver for successfully defending their dissertation and becoming Dr. Williams!
12/23/2022 – Congratulations to Myriam and Sara on their work on heteroarene hydrocarboxylation reaction that translates 2D heterocycles into versatile 3D analogs. Out on the rxiv now!
The rapid preparation of complex three-dimensional (3D) heterocyclic scaffolds is a key challenge in modern medicinal chemistry. Small molecule therapeutic candidates with increased 3D complexity, on average, possess a higher probability of clinical success. However, …