6/10/2021 – Congratulations to Alyah, Oliver, and Colleen on their work exploiting non-innocent radical anion intermediates in photoredox catalysis for promoting diverse coupling reactions of classically inert aryl chlorides. Out on JACS now!

We describe a photocatalytic system that elicits potent photoreductant activity from conventional photocatalysts by leveraging radical anion intermediates generated in situ. The combination of isophthalonitrile and sodium formate promotes diverse aryl radical coupling reactions from abundant but difficult to reduce aryl chloride substrates. Mechanistic studies reveal two parallel pathways for substrate reduction both enabled by a key terminal reductant byproduct, carbon dioxide radical anion.

Read the full article at: https://pubs-acs-org.ezproxy.library.wisc.edu/doi/10.1021/jacs.1c05988

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