Herein, we report a new class of electrophotocatalysts, polycyclic aromatic hydrocarbons, that promote the reduction of unactivated carbonyl compounds to generate versatile ketyl radical intermediates. This catalytic platform enables previously challenging intermolecular ketyl radical coupling …
Year: 2023
5/15/2023 – Congratulations to Sara, Jimin, Y, and Camille on developing a new catalytic system that unlocks hydrocarboxylation for unactivated alkenes!
Herein we disclose a strategy to promote the hydrocarboxylation of unactivated alkenes using photochemical activation of formate salts. We illustrate that an alternative initiation mechanism circumvents the limitations of prior approaches and enables hydrocarboxylation of …
5/15/2023 – Congratulations to Jimin, Y, and Uriel on passing the 2nd year Thesis Background Exam!
4/21/2023 – Congratulations to Dylan for successfully defending his dissertation and becoming Dr. Holst!
4/6/2023 – Congratulations to Dylan, Céline, Casey, and Ilia on developing a new platform for alkene aminofunctionalization!
Modular strategies to rapidly increase molecular complexity have proven immensely synthetically valuable. In principle, transformation of an alkene into a dielectrophile presents an opportunity to deliver two unique nucleophiles across an alkene. Unfortunately, the selectivity …
3/30/2023 – Congratulations to Joe on passing the 3rd year Research Proposal Exam!
3/24/2023 – Congratulations to Colleen for successfully defending her dissertation and becoming Dr. Chernowsky!
3/16/2023 – Congratulations to Minji, Diana, Karina, Uriel, Alison, and Ilia on developing a diastereoselective cyclopropanation method using the electrochemical dication pool strategy!
Cyclopropanes are desirable structural motifs with valuable applications in drug discovery and beyond. Established alkene cyclopropanation methods give rise to cyclopropanes with a limited array of substituents, are difficult to scale, or both. Herein, we …
2/25/2023 – Congratulations to Oliver, Alyah, Myriam, Charles, and Desiree on their work to develop a practical deoxygenation protocol with formate and light (and an acid promoter)!
A new protocol for alcohol deoxygenation that functions across a wide range of alcohol structures is reported. This approach combines the reductive potency of carbon dioxide radical anion with acidic additives to promote the kinetically …